News

01 April 2019 - Neurolixis CEO receives prize from startup showcase

Neurolixis CEO, Mark A. Varney PhD, was awarded a prize at an "Investor Speed Dating" event organized by Orange County Startup Council and supported by the Tech Coast Venture Network. Over 100 local companies participated as well as over 40 investors. Dr. Varney presented the drug development programs on NLX-112, which is being developed by Neurolixis for treatment of dyskinesia in Parkinson's disease.

Read the Orange County Startups article here.

12 March 2019 - FDA approves Neurolixis IND application for clinical trial with NLX-112

The US Food and Drug Administration (FDA) approved Neurolixis’ Investigational New Drug (IND) application for NLX-112. The FDA authorized a Phase 2 clinical study in Parkinson's disease patients with troublesome L-DOPA-induced dyskinesia. Neurolixis has previously shown that NLX-112 exhibits robust anti-dyskinetic activity in preclinical models of Parkinson's disease, without interfering with L-DOPA’s therapeutic properties. The planned clinical trial will investigate for the first time the safety and efficacy of NLX-112 in Parkinson's disease patients. Preparation and submission of the IND application was supported by funding from Parkinson’s UK, a non-profit charity which aims to improve life for everyone affected by Parkinson's disease through pioneering research and support services.

NLX-112 (also known as befiradol) acts on the brain’s serotonin system, and is a specific and efficacious activator of neuronal proteins known as 5-HT1A receptors. By targeting these receptors, NLX-112 inhibits L-DOPA-induced dyskinesia. NLX-112 is orally-administered and has previously been shown to be safe and well-tolerated in over 500 human subjects.

Read the full Neurolixis Press Release here.

Read the Parkinson’s UK announcement here.